Highly regioselective hydrogenolysis of bis (α-methylbenzyl) amine derivatives affected by the trifluoromethyl substituent on the aromatic ring

…, K Inomiya, Y Katsuhara, K Higashiyama, A Ishii

文献索引：Kanai, Masatomi; Yasumoto, Manabu; Kuriyama, Yokusu; Inomiya, Kenjin; Katsuhara, Yutaka; Higashiyama, Kimio; Ishii, Akihiro Organic Letters, 2003 , vol. 5, # 7 p. 1007 - 1010

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被引用次数: 35

摘要

The highly regioselective hydrogenolysis of bis (α-methylbenzyl) amine derivatives proceeded with influence not from the electronic effect but from the steric effect of the trifluoromethyl substituent on the aromatic ring to provide a practical asymmetric synthesis of trifluoromethyl-substituted α-phenylethylamines.