Microwave-assisted one step synthesis of 8-arylmethyl-9H-purin-6-amines

H Tao, Y Kang, T Taldone, G Chiosis

文献索引：Tao, Hui; Kang, Yanlong; Taldone, Tony; Chiosis, Gabriela Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 2 p. 415 - 417

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被引用次数: 16

摘要

Molecular chaperone heat shock protein 90 (Hsp90) is an important target in cancer and neurodegenerative diseases, and has rapidly become the focus of several drug discovery efforts. Among small molecule Hsp90 inhibitors with clinical applicability are derivatives of 8- arylmethyl-9H-purin-6-amine class. Here we report the use of microwave-assisted chemistry for the successful one-pot delivery of 8-arylmethyl-9H-purin-6-amines. We discuss the ...