A highly enantioselective synthesis of phosphate triesters

K Nakayama, WJ Thompson

文献索引：Nakayama, Kensaku; Thompson, Wayne J. Journal of the American Chemical Society, 1990 , vol. 112, # 19 p. 6936 - 6942

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被引用次数: 35

摘要

Abstract: A general methodology for the preparation of both enantiomers of a variety of trialkyl phosphates with enantiomeric exccsSes ranging from 87 to 92% is described. Bis (2, 4-dichlorophenyl) phosphoramidates bearing a 2-substituted pyrrolidine moiety as the chiral auxiliary are prepared and examined for their stereoselectivity. Considerations based on both the absolute configuration of the product phosphates as well as the X-ray structural ...