Enantioselective esterifications of unsaturated alcohols mediated by a lipase prepared from Pseudomonas sp

K Burgess, LD Jennings

文献索引：Burgess, Kevin; Jennings, Lee D. Journal of the American Chemical Society, 1991 , vol. 113, # 16 p. 6129 - 6139

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被引用次数: 332

摘要

Abstract: Competition experiments and measurements of enantioselectivities were used to develop a simple active-site model (Figure 1) for resolutions of 8-hydroxy-a-methylene carbonyl compounds 111 via acyl transfers mediated by lipase from Pseudomonas sp.(AK). Further experiments were used to test and refine this model with respect to resolutions of allylic, propargylic, homopropargylic, and other alcohols (Tables I-IV, respectively). The ...