Tetrahedron: Asymmetry

A new biocatalyst for the preparation of enantiomerically pure 2-arylpropanoic acids

I Kumar, K Manju, RS Jolly

文献索引：Kumar, Ish; Manju, Kavita; Jolly, Ravinder S. Tetrahedron Asymmetry, 2001 , vol. 12, # 10 p. 1431 - 1434

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被引用次数: 23

摘要

A new biocatalyst, a strain of Pseudomonas fluorescens MTCCB0015, is described, which produces ibuprofen, ketoprofen and flurbiprofen as enantiomerically pure (S)-2- arylpropanoic acids from their corresponding racemic esters. 2-Arylpropanoic acids are an important class of non-steroidal anti-inflammatory compounds, whose anti-inflammatory activity is mainly due to the (S)-enantiomer.