Synthesis and inhibition properties of a series of pyranose derivatives towards a Zn-metalloproteinase from Saccharomonosporacanescens

…, RJ Abdel-Jalil, RA Al-Qawasmeh, N Stambolieva…

文献索引：Dolashka-Angelova, Pavlina; Abdel-Jalil, Raid J.; Al-Qawasmeh, Raed A.; Stambolieva, Nicolina; Voelter, Wolfgang Carbohydrate Research, 2010 , vol. 345, # 16 p. 2343 - 2347

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被引用次数: 2

摘要

The Zn-proteinase, isolated from Saccharomonosporacanescens (NPS), shares many common features with thermolysin, but considerable differences are also evident, as far as the substrate recognition site is concerned. In substrates of general structure AcylAlaAlaPhe 4NA, this neutral proteinase cleaves only the arylamide bond (non-typical activity of Zn- proteinases), while thermolysin attacks the peptide bond Ala-Phe. Phosphoramidon is a ...