Highly selective directed hydrogenation of enantiopure 4-(tert-butoxycarbonylamino) cyclopent-1-enecarboxylic acid methyl esters

…, MC Lloyd, SJC Taylor, DA Chaplin, R McCague

文献索引：Smith, Mark E.B.; Derrien, Nadine; Lloyd, Michael C.; Taylor, Stephen J.C.; Chaplin, David A.; McCague, Raymond Tetrahedron Letters, 2001 , vol. 42, # 7 p. 1347 - 1350

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被引用次数: 26

摘要

The use of both N-tert-butoxycarbonylamino-and hydroxyl-directed hydrogenation methodology to yield essentially single diastereomers of 3-(tert-butoxycarbonylamino)-4- hydroxycyclopentanecarboxylic acid methyl esters and 3-(tert-butoxycarbonylamino) cyclopentanecarboxylic acid methyl esters is described. These results incorporate the first reported carbamate-directed hydrogenations of functionalised cyclopentenes.