Journal of Peptide Science

Synthesis and biological evaluation of analogues of the marine cyclic depsipeptide obyanamide

W Zhang, N Ding, Y Li

文献索引：Zhang, Wei; Ding, Ning; Li, Yingxia Journal of Peptide Science, 2011 , vol. 17, # 7 p. 533 - 539

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被引用次数: 2

摘要

Abstract On the basis of the total synthesis of obyanamide, 20 analogues of this marine cyclic depsipeptide have been synthesized by (i) preparation of the tripeptide fragments in the western hemisphere using Z/OtBu protocol;(ii) preparation of the dipeptide fragments in the eastern hemisphere using Boc/OMe protocol; and (iii) fragments coupling, removal of protecting groups (Boc and OtBu, in one pot), and macrocyclizaion in the last step. The ...