Synthesis and radioprotective properties of some 2-pyrrolidone derivatives

…, YM Bizunov, VI Emel'yanov, IL Knunyants

文献索引：Lisina, N. I.; Chernov, G. A.; Bizunov, Yu. M.; Emel'yanov, V. I.; Knunyants, I. L. Pharmaceutical Chemistry Journal, 1988 , vol. 22, # 6 p. 472 - 476 Khimiko-Farmatsevticheskii Zhurnal, 1988 , vol. 22, # 6 p. 705 - 710

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被引用次数: 1

摘要

The starting compound for obtaining IV is x-butyrolactone(I), from which the corresponding N- (e-hydrexyalkyl)-2-pyrrolidones IIa-c are obtained by reaction with amino alcohols. Compounds lla-c are converted to N-(w-haloalkyl)-2-pyrrolidones llla-d by treatment with SOCI= or PBra. The desired products are obtained by the reaction of llla-d with thiourea or sodium thiosulfate. In the treatment of lla, b with SOC12 the HCI liberated does not enter ...