Potentional anxiolytics and hypnotics: 1-(Alkanesulfonamidoalkyl)-6-aryl-8-halogeno-s-triazolo [4, 3-a]-1, 4-benzodiazepines and related compounds

…, J Holubek, M Buděšínský, E Svátek…

文献索引：Vejdelek, Zdenek; Metys, Jan; Holubek, Jiri; Budesinsky, Milos; Svatek, Emil; et al. Collection of Czechoslovak Chemical Communications, 1988 , vol. 53, # 1 p. 132 - 144

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摘要

Abstract 7-Chloro-5-phenyl-1, 3-dihydro-1, 4-benzodiazepin-2-thione and its 5-(2- chlorophenyl) and 7-bromo-5-(2-chlorophenyl) analogues were reacted with N- (methanesulfonyl)-and N-(ethanesulfonyl) glycine and–alanine hydrazides (X-XIII) in boiling butanol to give the title compounds Iabc-IVabc. The alanine-derived substances IIIabc and IVabc were characterized by 1 H NMR spectra as mixtures of two diastereoisomers. ...