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举例 :可输入Filippa Pettersson 或者 Cancer Res. 75(6) , 1102-12, (2015) 或者10.1002/anie.201600521

3-Aminopyridazine derivatives with atypical antidepressant, serotonergic and dopaminergic activities

CG Wermuth, G Schlewer, JJ Bourguignon…

文献索引：Wermuth; Schlewer; Bourguignon; Maghioros; Bouchet; Moire; Kan; Worms; Biziere Journal of Medicinal Chemistry, 1989 , vol. 32, # 3 p. 528 - 537

全文：HTML全文

被引用次数: 93

摘要

Minaprine [3-[(~-morpholinoethyl) amino]-4-methyl-6-phenylpyridazine dihydrochloride] is active in most animal models of depression and exhibits in vivo a dual dopaminomimetic and serotoninomimetic activity profile. In an attempt to dissociate these two effects and to ...

4-methyl-N-(2-morpholin-4-ylethyl)-6-(4-nitrophenyl)pyridazin-3-amine,dihydrochloride结构式

4-methyl-N-(2-m...

~59%

6-(4-aminophenyl)-4-methyl-N-(2-morpholin-4-ylethyl)pyridazin-3-amine dihydrochloride结构式

6-(4-aminopheny...

3-chloro-4-methyl-6-(4-nitrophenyl)pyridazine结构式

3-chloro-4-meth...

~%

6-(4-aminophenyl)-4-methyl-N-(2-morpholin-4-ylethyl)pyridazin-3-amine dihydrochloride结构式

6-(4-aminopheny...

2-hydroxy-2-methyl-4-oxo-4-(o-tolyl)butanoic acid结构式

2-hydroxy-2-met...

~%

4-methyl-6-(2-methylphenyl)-N-(2-morpholin-4-ylethyl)pyridazin-3-amine,dihydrochloride结构式

4-methyl-6-(2-m...

2-甲基乙酰苯酮结构式

2-甲基乙酰苯酮

~%

4-methyl-6-(2-methylphenyl)-N-(2-morpholin-4-ylethyl)pyridazin-3-amine,dihydrochloride结构式

4-methyl-6-(2-m...

4-methyl-6-(o-tolyl)pyridazin-3(2H)-one结构式

4-methyl-6-(o-t...

~%

4-methyl-6-(2-methylphenyl)-N-(2-morpholin-4-ylethyl)pyridazin-3-amine,dihydrochloride结构式

4-methyl-6-(2-m...

2-氨乙基吗啉结构式

2-氨乙基吗啉

3-chloro-4-methyl-6-(o-tolyl)pyridazine结构式

3-chloro-4-meth...

~%

4-methyl-6-(2-methylphenyl)-N-(2-morpholin-4-ylethyl)pyridazin-3-amine,dihydrochloride结构式

4-methyl-6-(2-m...

苯基丙酮结构式

~%

6-benzyl-4-methyl-N-(2-morpholin-4-ylethyl)pyridazin-3-amine,dihydrochloride结构式

6-benzyl-4-meth...

6-benzyl-4-methylpyridazin-3(2H)-one结构式

6-benzyl-4-meth...

~%

6-benzyl-4-methyl-N-(2-morpholin-4-ylethyl)pyridazin-3-amine,dihydrochloride结构式

6-benzyl-4-meth...

2-氨乙基吗啉结构式

2-氨乙基吗啉

6-benzyl-3-chloro-4-methyl-pyridazine结构式

6-benzyl-3-chlo...

~%

6-benzyl-4-methyl-N-(2-morpholin-4-ylethyl)pyridazin-3-amine,dihydrochloride结构式

6-benzyl-4-meth...

(E)-3-(4-chlorobenzylidene)-5-phenylfuran-2(3H)-one结构式

(E)-3-(4-chloro...

~%

5-[(4-chlorophenyl)methyl]-3-phenyl-1H-pyridazin-6-one结构式

5-[(4-chlorophe...

对氯苯甲醛结构式

对氯苯甲醛

~%

5-[(4-chlorophenyl)methyl]-3-phenyl-1H-pyridazin-6-one结构式

5-[(4-chlorophe...

3-苯甲酰丙酸结构式

3-苯甲酰丙酸

~%

5-[(4-chlorophenyl)methyl]-3-phenyl-1H-pyridazin-6-one结构式

5-[(4-chlorophe...

3-氯-4-甲基-6-苯基哒嗪结构式

3-氯-4-甲基-6-苯基哒嗪

N,N'-二正丙基乙二胺结构式

N,N'-二正丙基乙二胺

~%

N'-(4-Methyl-6-phenyl-3-pyridazinyl)-N,N-dipropyl-1,2-ethanediami ne ethanedioate (1:2)结构式

N'-(4-Methyl-6-...

2-氨乙基吗啉结构式

2-氨乙基吗啉

3-chloro-4-methyl-6-(p-tolyl)pyridazine结构式

3-chloro-4-meth...

~%

4-methyl-6-(4-methylphenyl)-N-(2-morpholin-4-ylethyl)pyridazin-3-amine,dihydrochloride结构式

4-methyl-6-(4-m...

3-(o-chlorobenzylidene)-5-phenylfuran-2(3H)-one结构式

3-(o-chlorobenz...

~%

4-[(2-chlorophenyl)methyl]-N-(2-morpholin-4-ylethyl)-6-phenylpyridazin-3-amine,dihydrochloride结构式

4-[(2-chlorophe...

邻氯苯甲醛结构式

邻氯苯甲醛

~%

4-[(2-chlorophenyl)methyl]-N-(2-morpholin-4-ylethyl)-6-phenylpyridazin-3-amine,dihydrochloride结构式

4-[(2-chlorophe...

3-苯甲酰丙酸结构式

3-苯甲酰丙酸

~%

4-[(2-chlorophenyl)methyl]-N-(2-morpholin-4-ylethyl)-6-phenylpyridazin-3-amine,dihydrochloride结构式

4-[(2-chlorophe...

4-(2-Chlorobenzyl)-6-phenyl-3(2H)-pyridazinone结构式

4-(2-Chlorobenz...

~%

4-[(2-chlorophenyl)methyl]-N-(2-morpholin-4-ylethyl)-6-phenylpyridazin-3-amine,dihydrochloride结构式

4-[(2-chlorophe...

2-氨乙基吗啉结构式

2-氨乙基吗啉

3-chloro-4-(4-chlorobenzyl)-6-phenylpyridazine结构式

3-chloro-4-(4-c...

~%

4-[(2-chlorophenyl)methyl]-N-(2-morpholin-4-ylethyl)-6-phenylpyridazin-3-amine,dihydrochloride结构式

4-[(2-chlorophe...

对氟苯乙酮结构式

对氟苯乙酮

~%

6-(4-fluorophenyl)-4-methyl-N-(2-morpholin-4-ylethyl)pyridazin-3-amine,dihydrochloride结构式

6-(4-fluorophen...

6-(4-fluoro-phenyl)-4-methyl-2H-pyridazin-3-one结构式

6-(4-fluoro-phe...

~%

6-(4-fluorophenyl)-4-methyl-N-(2-morpholin-4-ylethyl)pyridazin-3-amine,dihydrochloride结构式

6-(4-fluorophen...

2'-甲氧基苯乙酮结构式

2'-甲氧基苯乙酮

~%

6-(2-methoxyphenyl)-4-methyl-N-(2-morpholin-4-ylethyl)pyridazin-3-amine,dihydrochloride结构式

6-(2-methoxyphe...

6-苯基-2H-哒嗪-3-酮-4-羧酸乙酯结构式

6-苯基-2H-哒嗪-3-酮-...

~85%

6-oxo-3-phenyl-1H-pyridazine-5-carboxamide结构式

6-oxo-3-phenyl-...

ethyl 3-oxo-6-phenyl-2,3,4,5-tetrahydropyridazine-4-carboxylate结构式

ethyl 3-oxo-6-p...

~%

6-oxo-3-phenyl-1H-pyridazine-5-carboxamide结构式

6-oxo-3-phenyl-...

diethyl 2-phenacylpropanedioate结构式

diethyl 2-phena...

~%

6-oxo-3-phenyl-1H-pyridazine-5-carboxamide结构式

6-oxo-3-phenyl-...

diethyl 2-phenacylpropanedioate结构式

diethyl 2-phena...

~58%

ethyl 3-oxo-6-phenyl-2,3,4,5-tetrahydropyridazine-4-carboxylate结构式

ethyl 3-oxo-6-p...

2-乙酰基噻吩结构式

2-乙酰基噻吩

~%

4-methyl-N-(2-morpholin-4-ylethyl)-6-thiophen-2-ylpyridazin-3-amine,dihydrochloride结构式

4-methyl-N-(2-m...

2-hydroxy-2-methyl-4-oxo-4-thiophen-2-yl-butyric acid结构式

2-hydroxy-2-met...

~%

4-methyl-N-(2-morpholin-4-ylethyl)-6-thiophen-2-ylpyridazin-3-amine,dihydrochloride结构式

4-methyl-N-(2-m...

4-methyl-6-(2-thienyl)pyridazin-3-one结构式

4-methyl-6-(2-t...

~%

4-methyl-N-(2-morpholin-4-ylethyl)-6-thiophen-2-ylpyridazin-3-amine,dihydrochloride结构式

4-methyl-N-(2-m...

2-氨乙基吗啉结构式

2-氨乙基吗啉

3-chloro-4-methyl-6-(thien-2-yl)pyridazine结构式

3-chloro-4-meth...

~%

4-methyl-N-(2-morpholin-4-ylethyl)-6-thiophen-2-ylpyridazin-3-amine,dihydrochloride结构式

4-methyl-N-(2-m...

2-氨乙基吗啉结构式

2-氨乙基吗啉

3-chloro-4-methyl-6-(4-nitrophenyl)pyridazine结构式

3-chloro-4-meth...

~%

4-methyl-N-(2-morpholin-4-ylethyl)-6-(4-nitrophenyl)pyridazin-3-amine,dihydrochloride结构式

4-methyl-N-(2-m...

邻氟苯乙酮结构式

邻氟苯乙酮

~%

6-(2-fluorophenyl)-4-methyl-N-(2-morpholin-4-ylethyl)pyridazin-3-amine,dihydrochloride结构式

6-(2-fluorophen...

6-(2-fluorophenyl)-4-methylpyridazin-3(2H)-one结构式

6-(2-fluorophen...

~%

6-(2-fluorophenyl)-4-methyl-N-(2-morpholin-4-ylethyl)pyridazin-3-amine,dihydrochloride结构式

6-(2-fluorophen...

2-氨乙基吗啉结构式

2-氨乙基吗啉

3-chloro-6-(2-fluorophenyl)-4-methylpyridazine结构式

3-chloro-6-(2-f...

~%

6-(2-fluorophenyl)-4-methyl-N-(2-morpholin-4-ylethyl)pyridazin-3-amine,dihydrochloride结构式

6-(2-fluorophen...

2-hydroxy-2-methyllevulinic acid结构式

2-hydroxy-2-met...

~%

4,6-dimethyl-N-(2-morpholin-4-ylethyl)pyridazin-3-amine,dihydrochloride结构式

4,6-dimethyl-N-...

4,6-二甲基-2,3-二氢哒嗪-3-酮结构式

4,6-二甲基-2,3-二氢哒嗪-3-酮

~%

4,6-dimethyl-N-(2-morpholin-4-ylethyl)pyridazin-3-amine,dihydrochloride结构式

4,6-dimethyl-N-...

2-氨乙基吗啉结构式

2-氨乙基吗啉

3-氯-4,6-二甲基哒嗪结构式

3-氯-4,6-二甲基哒嗪

~%

4,6-dimethyl-N-(2-morpholin-4-ylethyl)pyridazin-3-amine,dihydrochloride结构式

4,6-dimethyl-N-...

2-氨乙基吗啉结构式

2-氨乙基吗啉

3-chloro-4-ethyl-6-phenylpyridazine结构式

3-chloro-4-ethy...

~%

4-ethyl-N-(2-morpholin-4-ylethyl)-6-phenylpyridazin-3-amine,dihydrochloride结构式

4-ethyl-N-(2-mo...

1-(2-氨乙基)吡咯烷结构式

1-(2-氨乙基)吡咯烷

3-氯-4-甲基-6-苯基哒嗪结构式

3-氯-4-甲基-6-苯基哒嗪

~%

4-methyl-6-phenyl-N-(2-pyrrolidin-1-ylethyl)pyridazin-3-amine,dihydrochloride结构式

4-methyl-6-phen...

1-(2-氨基乙基)哌啶结构式

1-(2-氨基乙基)哌啶

3-氯-4-甲基-6-苯基哒嗪结构式

3-氯-4-甲基-6-苯基哒嗪

~%

4-methyl-6-phenyl-N-(2-piperidin-1-ylethyl)pyridazin-3-amine,dihydrochloride结构式

4-methyl-6-phen...

(E)-3-(4-chlorobenzylidene)-5-phenylfuran-2(3H)-one结构式

(E)-3-(4-chloro...

~%

4-[(4-chlorophenyl)methyl]-N-(2-morpholin-4-ylethyl)-6-phenylpyridazin-3-amine,dihydrochloride结构式

4-[(4-chlorophe...

对氯苯甲醛结构式

对氯苯甲醛

~%

4-[(4-chlorophenyl)methyl]-N-(2-morpholin-4-ylethyl)-6-phenylpyridazin-3-amine,dihydrochloride结构式

4-[(4-chlorophe...

3-苯甲酰丙酸结构式

3-苯甲酰丙酸

~%

4-[(4-chlorophenyl)methyl]-N-(2-morpholin-4-ylethyl)-6-phenylpyridazin-3-amine,dihydrochloride结构式

4-[(4-chlorophe...

5-[(4-chlorophenyl)methyl]-3-phenyl-1H-pyridazin-6-one结构式

5-[(4-chlorophe...

~%

4-[(4-chlorophenyl)methyl]-N-(2-morpholin-4-ylethyl)-6-phenylpyridazin-3-amine,dihydrochloride结构式

4-[(4-chlorophe...

2-氨乙基吗啉结构式

2-氨乙基吗啉

3-chloro-4-(2-chlorobenzyl)-6-phenylpyridazine结构式

3-chloro-4-(2-c...

~%

4-[(4-chlorophenyl)methyl]-N-(2-morpholin-4-ylethyl)-6-phenylpyridazin-3-amine,dihydrochloride结构式

4-[(4-chlorophe...

3-甲氧基苯乙酮结构式

3-甲氧基苯乙酮

~%

6-(3-methoxyphenyl)-4-methyl-N-(2-morpholin-4-ylethyl)pyridazin-3-amine,dihydrochloride结构式

6-(3-methoxyphe...

2-氨乙基吗啉结构式

2-氨乙基吗啉

3-chloro-4-methyl-6-naphthalen-1-yl-pyridazine结构式

3-chloro-4-meth...

~%

4-methyl-N-(2-morpholin-4-ylethyl)-6-naphthalen-1-ylpyridazin-3-amine,dihydrochloride结构式

4-methyl-N-(2-m...

ethyl 3-oxo-6-phenyl-2,3,4,5-tetrahydropyridazine-4-carboxylate结构式

ethyl 3-oxo-6-p...

~58%

6-苯基-2H-哒嗪-3-酮-4-羧酸乙酯结构式

6-苯基-2H-哒嗪-3-酮-...

diethyl 2-phenacylpropanedioate结构式

diethyl 2-phena...

~%

6-苯基-2H-哒嗪-3-酮-4-羧酸乙酯结构式

6-苯基-2H-哒嗪-3-酮-...