Application of [3+ 2]-Cycloaddition in the Synthesis of Valdecoxib

…, G Goverdhan, A Sampath, K Mukkanti…

文献索引：Reddy, Anumula Raghupathi; Goverdhan, Gilla; Sampath, Aalla; Mukkanti, Khagga; Reddy, Padi Pratap; Bandichhor, Rakeshwar Synthetic Communications, 2012 , vol. 42, # 5 p. 639 - 649

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被引用次数: 5

摘要

Valdecoxib 1 (Fig. 1) is a nonsteroidal anti-inflammatory drug (NSAID), which acts as an inhibitor of cyclooxygenase-2 (COX-2), although in practice it is used for the treatment of rheumatoid arthritis, osteoarthritis, and dysmenorrhea. [ 1–3 View all references ] Several synthetic procedures for valdecoxib 1 are known. Apart from utilizing dipolar cycloaddition, most of the synthetic methods involve either industrially nonviable reagents such as butyl lithium, [ 4 4. Talley , JJ ; ...