Tyrosine-sulfate isosteres of CCR5 N-terminus as tools for studying HIV-1 entry

…, P Acharya, R Wyatt, PD Kwong, CA Bewley

文献索引：Lam, Son N.; Acharya, Priyamvada; Wyatt, Richard; Kwong, Peter D.; Bewley, Carole A. Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 23 p. 10113 - 10120

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被引用次数: 33

摘要

The HIV-1 co-receptor CCR5 possesses sulfo-tyrosine (TYS) residues at its N-terminus (Nt) that are required for binding HIV-1 gp120 and mediating viral entry. By using a 14-residue fragment of CCR5 Nt containing two TYS residues, we recently showed that CCR5 Nt binds gp120 through a conserved region specific for TYS moieties and suggested that this site may represent a target for inhibitors and probes of HIV-1 entry. As peptides containing ...