Indolin-2-one p38α inhibitors I: Design, profiling and crystallographic binding mode

…, R Roca, C Balagué, A Orellana, M Domínguez

文献索引：Eastwood, Paul; Gonzalez, Jacob; Gomez, Elena; Vidal, Bernat; Caturla, Francisco; Roca, Ramon; Balague, Cristina; Orellana, Adelina; Dominguez, Maria Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 14 p. 4130 - 4133

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被引用次数: 12

摘要

Download PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... The use of structure-based design and molecular modeling led to the discovery of indolin-2-one derivatives as potent and selective p38α inhibitors. The predicted binding mode was confirmed by X-ray crystallography. ... The use of structure-based design and molecular modeling led to the ...