Sequential acetic acid–sodium chloride treatment to control salt stoichiometry of a hydrochloride salt
DM Caine, IL Paternoster, S Sedehizadeh…
文献索引：Caine, Darren M.; Paternoster, Ian L.; Sedehizadeh, Simon; Shapland, Peter D. P. Organic Process Research and Development, 2012 , vol. 16, # 3 p. 518 - 523
The sequential treatment of an intermediate in the synthesis of GSK159797 with a protic acid and sodium chloride was developed to control the stoichiometry of the hydrochloric acid salt of the API. This offered significant advantages over addition of hydrochloric acid, thus ...
