Bioorganic & medicinal chemistry letters

Catechol-substituted L-chicoric acid analogues as HIV integrase inhibitors

JY Lee, KJ Yoon, YS Lee

文献索引：Lee, Jae Yeol; Yoon, Kwon Joong; Lee, Yong Sup Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 24 p. 4331 - 4334

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被引用次数: 35

摘要

HIV integrase catalyzes the integration of HIV DNA copy into the host cell DNA, which is essential for the production of progeny viruses. l-Chicoric acid and dicaffeoylquinic acids, isolated from plants, are well known potent inhibitors of HIV integrase. The common structural features of these inhibitors are caffeic acid derivatives connected to tartaric acid or quinic acid through ester bonds. In the present study, we have synthesized and tested the ...