Combination of Olefin Metathesis and Enzymatic Ester Hydrolysis in Aqueous Media in a One??Pot Synthesis

K Tenbrink, M Seßler, J Schatz…

文献索引：Tenbrink, Katharina; Sessler, Miriam; Schatz, Juergen; Groeger, Harald Advanced Synthesis and Catalysis, 2011 , vol. 353, # 13 p. 2363 - 2367

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被引用次数: 25

摘要

Abstract A new synthetic method for the preparation of cyclic malonic acid monoesters in aqueous media was developed based on the combination of a metathesis reaction and subsequent biocatalytic hydrolysis with a pig liver esterase in a one-pot synthesis. Both reaction steps proceed smoothly under optimized conditions in aqueous media requiring only a low amount of the metal catalyst for the metathesis reaction. Notably, the applied ...