Synthesis and SAR comparison of regioisomeric aryl naphthyridines as potent mGlu5 receptor antagonists

…, RM Brooker, CE Augelli-Szafran, RD Schwarz…

文献索引：Galatsis, Paul; Yamagata, Koji; Wendt, John A.; Connolly, Cleo J.; Mickelson, John W.; Milbank, Jared B.J.; Bove, Susan E.; Knauer, Christopher S.; Brooker, Rachel M.; Augelli-Szafran, Corinne E.; Schwarz, Roy D.; Kinsora, Jack J.; Kilgore, Kenneth S. Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 23 p. 6525 - 6528

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被引用次数: 13

摘要

Download PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... We describe three novel regioisomeric series of aryl naphthyridine analogs, which are potent antagonists of the Class III GPCR mGlu5 receptor. The synthesis and in vitro and in vivo pharmacological activities of these analogs are discussed. ... We describe three novel regioisomeric ...