Structure-activity relationship of N-[2-(dimethylamino)-6-[3-(5-methyl-4-phenyl-1H-imidazol-1-yl) propoxy] phenyl]-N'-pentylurea and analogs. Novel potent inhibitors of …
We have discovered N-butyl-N'-[2-(dimethylamino)-6-[3-(4-phenyl-1H-imidazol-l-yl) propoxy]- phenyl] urea (4), a novel, potent, and systemically bioavailable inhibitor of ACAT (acylCoA: cholesterol 0-acyltransferase). The structure-activity relationships (SARs) of this lead compound 4 were investigated by systematic modification of four regions in the molecule. The compounds prepared in this study were tested for in vitro inhibitory activity toward ...
