Synthesis, characterization and vasculoprotective effects of nitric oxide-donating derivatives of chrysin

…, SM Peng, CP Hu, LF Tan, Q Yuan, HW Deng…

文献索引：Zou, Xiao-Qing; Peng, Sheng-Ming; Hu, Chang-Ping; Tan, Li-Feng; Yuan, Qiong; Deng, Han-Wu; Li, Yuan-Jian Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 9 p. 3020 - 3025

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被引用次数: 20

摘要

Vascular complications are major causes of disability and death in patients with diabetes mellitus. It is often characterized by endothelial dysfunction. Studies have shown that either the loss of nitric oxide bioactivity or the decreased biosynthesis of NO is a central mechanism in endothelial dysfunction. As such, the delivery of exogenous NO is an attractive therapeutic option that has been used to slow the progress of diabetic vascular ...