An efficient synthesis of a potent candidate in our respiratory program is described. The synthesis based on a key Darzens condensation− α, β-epoxide rearrangement circumvented the toxicity and safety issues encountered in the original synthesis route. Subsequent functionalization and formation of an heterocyclic moiety is presented with a particular emphasis on the practicality, robustness, and streamlining of the process.
![N-[5-(3-fluoro-4-methylsulfonylphenyl)-4-methyl-1,3-thiazol-2-yl]acetamide结构式](https://image.chemsrc.com/caspic/350/593959-19-4.png)
