Tetrahedron: Asymmetry

Chiral ligands containing heteroatoms. 11. Optically active 2-hydroxymethyl piperazincs as catalysts in the enantioselective addition of diethylzinc to benzaldehyde

M Falorni, M Satta, S Conti, G Giacomelli

文献索引：Falorni, Massimo; Satta, Michele; Conti, Sandra; Giacomelli, Giampaolo Tetrahedron: Asymmetry, 1993 , vol. 4, # 11 p. 2389 - 2398

全文：HTML全文

被引用次数: 20

摘要

Abstract Starting from enantiomerically pure serine, a series of (2R, 5S) and (2S, 5S)-2- hydroxymethyl-5-alkyl piperazines 1–5 were prepared in good yields without any racemization. The use of these compounds as chiral catalysts for the enantioselective addition of diethylzinc to aldehydes is described. This paper reports the first example of the use of piperazine methanols in asymmetric synthesis.