Studies on chemotherapeutics I. Synthesis of 5??substituted??4??oxo??1, 4??dihydro??3??pyridinecarboxylic acid derivatives

MÁR Balogh, I Hermecz, Z Mészaros…

文献索引：Balogh; Hermecz; Meszaros; et al. Journal of Heterocyclic Chemistry, 1980 , vol. 17, # 2 p. 359 - 368

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被引用次数: 9

摘要

Abstract Ethyl 5-substituted-4-oxo-1, 4-dihydro-3-pyridinecarboxylates were synthetized by reacting 1, 3, 5-triazine with 4-substituted ethyl acetoacetate derivatives in ethanol, in the presence of sodium ethoxide. The l-alkyl-5-substituted-4-oxo-1, 4-dihydro-3- pyridinecarboxylic acids required for the antimicrobial studies were prepared by N-alkylation (with triethyl phosphate or alkyl halides) and alkaline hydrolysis of the pyridone esters.