A detailed structure-activity relationship is revealed for resolved, centrally acting dopamine (DA) agonists acting on both pre-and postsynaptic DA receptors. The compounds resolved are 5-and 7-hydroxy-2-(di-n-propylamino) tetralin and cis-and trans-7-hydroxy-4-n-propyl-1, 2, 3, 4, 4a, 5, 6, l0b-octahydrobenzo~ quinoline. By the superimposition of the structures of the more active enantiomers of these compounds with those of known dopaminergic ...
