Direct β-Alkylation of Secondary Alcohols with Primary Alcohols Catalyzed by a Cp* Ir Complex

…, C Asai, T Yamaguchi, F Hanasaka, R Yamaguchi

文献索引：Fujita, Ken-Ichi; Asai, Chiho; Yamaguchi, Tetsuhiro; Hanasaka, Fumihiro; Yamaguchi, Ryohei Organic Letters, 2005 , vol. 7, # 18 p. 4017 - 4019

全文：HTML全文

被引用次数: 144

摘要

A new catalytic system for β-alkylation of secondary alcohols has been developed. In the presence of [Cp* IrCl2] 2 (Cp*= pentamethylcyclopentadienyl) catalyst and base, the reactions of various secondary alcohols with primary alcohols give β-alkylated higher alcohols in good to excellent yields without any hydrogen acceptor or hydrogen donor. This reaction proceeds via successive hydrogen-transfer reactions and aldol condensation.