Journal of medicinal chemistry

Synthesis and carcinogenicity of compounds related to 6-hydroxymethylbenzo [a] pyrene

RK Natarajan, JW Flesher

文献索引：Natarajan,R.K.; Flesher,J.W. Journal of Medicinal Chemistry, 1973 , vol. 16, p. 714 - 715

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被引用次数: 29

摘要

714 Journal of Medicinal Chemistry, I9 73, Vol. 16, No. 6 Notes modification of the method of Hoard and Ott” was used to prepare the triphosphate. The tripentylammonium salt of 5 (0.1 mmol) was dissolved in 3 ml of dry DMF and to this solution was added 160 mg (1.0 mmol) of l, l'-carbonyldiimidazole. The mixture was allowed to stand overnight and then treated simultaneously with MeOH (73 MI, 1.8 mmol) and tripentylammonium pyrophosphate (1.0 ...