Tetrahedron letters

Regioselective synthesis of (±)-gabaculine hydrochloride

G Frater, U Müller, U Schöpfer

文献索引：Frater, G.; Mueller, U.; Schoepfer, U. Tetrahedron Letters, 1984 , vol. 25, # 3 p. 281 - 284

全文：HTML全文

被引用次数: 3

摘要

Abstract 3-Cyclohexenecarboxylic acid (2) has been functionalized to the protected amino acid 5 in a novel reaction sequence, the crucial step being the acid catalysed cyclization of the γ, δ-unsaturated isocyanate 3 to the bicyclic lactam 4. 5 was converted into gabaculine hydrochloride (1· HCl).