The Journal of Organic Chemistry

Preparation of novel 4-substituted 6-methoxy-, 6, 7-dimethoxy-, and 6, 7-(methylenedioxy) isochroman-3-ones. 2

SP Khanapure, ER Biehl

文献索引：Khanapure, Subhash P.; Biehl, Edward R. Journal of Organic Chemistry, 1990 , vol. 55, # 5 p. 1471 - 1475

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被引用次数: 23

摘要

The titled compounds 20, 21, and 22 have been prepared in modest yields by a two-step reaction involving first the reaction of bromoarenes 3, 7, and 8 with lithioalkyl-and lithioarylacetonitriles under aryne-forming conditions. The cyano products 10, 14. and 16 so formed were then converted to the corresponding isochroman-3-ones by acidic hydrolysis.