Tetrahedron

Synthèse par réaction s RN 1 de nouveaux dérivés en série imidazo [1, 2-α] pyridine à potentialités pharmacologiques

…, N Madadi, C Roubaud, J Maldonado, MP Crozet

文献索引：Vanelle; Madadi; Roubaud; Maldonado; Crozet Tetrahedron, 1991 , vol. 47, # 28 p. 5173 - 5184

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被引用次数: 35

摘要

The study of SRN1 reaction between 2-chloromethyl-3-nitroimidazo [1, 2-a] pyridine and 2- nitropropane salts has been extended to various aliphatic, cyclic and heterocyclic nitronate anions. From C-alkylation products, base-promoted nitrous acid elimination afforded new potential pharmacological derivatives with a trisubstituted double bond at the 2 position.