Scalable synthesis of cortistatin A and related structures
…, G Manolikakes, CH Yeh, CA Guerrero…
文献索引：Shi, Jun; Manolikakes, Georg; Yeh, Chien-Hung; Guerrero, Carlos A.; Shenvi, Ryan A.; Shigehisa, Hiroki; Baran, Phil S. Journal of the American Chemical Society, 2011 , vol. 133, # 20 p. 8014 - 8027
Full details are provided for an improved synthesis of cortistatin A and related structures as well as the underlying logic and evolution of strategy. The highly functionalized cortistatin A- ring embedded with a key heteroadamantane was synthesized by a simple and scalable five- step sequence. A chemoselective, tandem geminal dihalogenation of an unactivated methyl group, a reductive fragmentation/trapping/elimination of a bromocyclopropane, and a ...
