Pyrazolo [1, 5-a] pyrimidines: estrogen receptor ligands possessing estrogen receptor β antagonist activity

DR Compton, S Sheng, KE Carlson…

文献索引：Journal of Medicinal Chemistry, , vol. 47, # 24 p. 5872 - 5893

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被引用次数: 120

摘要

... Journal of Medicinal Chemistry. ... The ER is a pharmaceutical target of interest for the prevention and treatment of breast cancer, as well as for hormone replacement therapy to prevent osteoporosis and mitigate menopausal symptoms. ...