Organic letters

Rhodium (I)-catalyzed ene-allene carbocyclization strategy for the formation of azepines and oxepines

KM Brummond, H Chen, B Mitasev, AD Casarez

文献索引：Brummond, Kay M.; Chen, Hongfeng; Mitasev, Branko; Casarez, Anthony D. Organic Letters, 2004 , vol. 6, # 13 p. 2161 - 2163

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被引用次数: 53

摘要

A novel strategy for the preparation of seven-membered heterocyclic compounds has been realized. Treatment of ene-allene 1 with a catalytic quantity of rhodium biscarbonyl chloride dimer affords the cyclization product 2 in moderate to high yields. The scope and limitations of this new method are currently under investigation, and the results obtained to date are discussed within.