Synthesis and biological evaluation of new cytotoxic azanaphthoquinone pyrrolo-annelated derivatives

…, W Holzer, H Spreitzer, P Schmidt, B Aicher…

文献索引：Shanab, Karem; Schirmer, Eva; Knafl, Heike; Wulz, Eva; Holzer, Wolfgang; Spreitzer, Helmut; Schmidt, Peter; Aicher, Babette; Mueller, Gilbert; Guenther, Eckhard Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 13 p. 3950 - 3952

全文：HTML全文

被引用次数: 10

摘要

Mitoxantrone is a widely used anticancer agent. 1 and 2 The most distinctive disadvantage of this intercalating drug molecule is cardiotoxicity. 3 It seems that a solution of this problem has been found by the development of BBR2778 (Pixantrone) which is currently in phase III clinical trials in patients with Non-Hodgkin's Lymphoma. 4 This compound exhibits less cardiotoxicity 5 and it is evident that this advantage is based on the substitution of the 5,8-dihydroxy ...