Synlett

Pd-Catalyzed Cross-Coupling Reactions of Pyridine Carboxylic Acid Chlorides with Alkylzinc Reagents

T Iwai, T Nakai, M Mihara, T Ito, T Mizuno, T Ohno

文献索引：Iwai, Toshiyuki; Nakai, Takeo; Mihara, Masatoshi; Ito, Takatoshi; Mizuno, Takumi; Ohno, Toshinobu Synlett, 2009 , # 7 p. 1091 - 1094

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摘要

Abstract The efficient cross-coupling reaction to afford ketones from pyridine carboxylic acid chlorides and alkylzinc reagents in the presence of Pd (phen) Cl 2 is reported. In the case of chloronicotinoyl chlorides, none of Negishi cross-coupling products of 2-chloroazine moiety was formed. The catalyst loading could be reduced up to 0.01 mol%.