Antiproliferative, antiandrogenic and cytotoxic effects of novel caffeic acid derivatives in LNCaP human androgen-dependent prostate cancer cells

…, C Patton, G Lassalle-Claux, J Jean-François…

文献索引：Sanderson, J. Thomas; Clabault, Helene; Patton, Cody; Lassalle-Claux, Gregoire; Jean-Francois, Jacques; Pare, Aurelie F.; Hebert, Martin J.G.; Surette, Marc E.; Touaibia, Mohamed Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 22 p. 7182 - 7193

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被引用次数: 19

摘要

Abstract Caffeic acid and its naturally occurring derivative caffeic acid phenethyl ester (CAPE) have antiproliferative and cytotoxic properties in a variety of cancer cell lines without displaying significant toxicity toward healthy cells, and are considered to be potential anticancer agents. However, little is known about their effects on prostate cancer cells. We synthesized and evaluated the effects of caffeic acid, CAPE (2) and 18 synthetic ...