Synthesis and biological properties of 6-substituted N 1-benzyl-N 3-methyluracils

RG Melik-Ogandzhanyan, VÉ Khachatryan…

文献索引：Melik-Ogandzhanyan, R. G.; Khachatryan, V. E.; Israelyan, S. G.; Paronikyan, R. V.; Ter-Zakharyan, Yu. Z.; et al. Pharmaceutical Chemistry Journal, 1989 , vol. 23, # 3 p. 235 - 238 Khimiko-Farmatsevticheskii Zhurnal, 1989 , vol. 23, # 3 p. 302 - 304

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摘要

In a lengthy study searching for new biologically-active compounds in the N-benzyluracil series [i, 6, 7], we undertook the synthesis of 6-substituted N1-(3-R-4-methoxybenzyl)-N 3- methyluracils (la-c, lla-e, and Ilia-d). The choice of these compounds was directed by the fact that some of our earlier-synthesized N-benzyluracils showed significant antitumor activity [i, 6] and N-sulfonylphenyluracil possessed antibacterial activity [5]. Further, information is ...