Water-soluble renin inhibitors: design of a subnanomolar inhibitor with a prolonged duration of action

SH Rosenberg, KW Woods, HL Sham…

文献索引：Rosenberg, Saul H.; Woods, Keith W.; Sham, Hing L.; Kleinert, Hollis D.; Martin, Donald L.; et al. Journal of Medicinal Chemistry, 1990 , vol. 33, # 7 p. 1962 - 1969

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被引用次数: 26

摘要

Incorporation of nonreactive polar functionalities at the C-and N-termini of renin inhibitors led to the development of a subnanomolar compound (2 1) with millimolar solubility. This inhibitor demonstrated excellent efficacy and a long duration of action upon intravenous ...