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Potassium phosphate or silica sulfuric acid catalyzed conjugate addition of thiols to α, β-unsaturated ketones at room temperature under solvent-free conditions

DM Pore, MS Soudagar, UV Desai, TS Thopate…

文献索引:Pore; Soudagar; Desai; Thopate; Wadagaonkar Tetrahedron Letters, 2006 , vol. 47, # 52 p. 9325 - 9328

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被引用次数: 41

摘要

Potassium phosphate and silica sulfuric acid have been found to be useful and highly efficient catalysts for conjugate addition of thiols to α, β-unsaturated ketones under solvent- free conditions, at room temperature. Silica sulfuric acid (SSA) was found to be suitable for electron-deficient enones while potassium phosphate was found to effect thia-Michael addition with both, electron-deficient as well as electron-rich conjugated ketones.