Concise Synthesis of 5-Methoxy-6-hydroxy-2-methylchromone-7-O-and 5-Hydroxy-2-methylchromone-7-O-rutinosides. Investigation of Their Cytotoxic Activities …

B Wu, W Zhang, Z Li, L Gu, X Wang…

文献索引：Wu, Baolin; Zhang, Wenpeng; Li, Zhonghua; Gu, Li; Wang, Xin; Wang, Peng George Journal of Organic Chemistry, 2011 , vol. 76, # 7 p. 2265 - 2268

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被引用次数: 5

摘要

The synthesis of two novel 2-methylchromone-7-O-rutinosides is reported, and the in vitro biological activities of these compounds and their synthetic precursors have been investigated on the basis of their cytotoxicity against several human tumor cell lines. The synthesis features early stage assembly of the acidic labile glycosidic bond between sugar and 2-methylchromone aglycon under phase transfer catalyzed glycosidation conditions, ...