Synthesis and antitumor activity of 4-aminomethylthioxanthenone and 5-aminomethylbenzothiopyranoindazole derivatives

…, KM Klingbeil, AD Peverly, RG Robinson…

文献索引：Perni, Robert B.; Wentland, Mark P.; Huang, Jianhua I.; Powles, Ronald G.; Aldous, Suzanne; Klingbeil, Kristina M.; Peverly, A. Danielle; Robinson, Ronald G.; Corbett, Thomas H.; Jones, Julie L.; Mattes, Kenneth C.; Rake, James B.; Coughlin, Susan A. Journal of Medicinal Chemistry, 1998 , vol. 41, # 19 p. 3645 - 3654

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被引用次数: 21

摘要

Two new series of antitumor agents, 4-aminomethylthioxanthenones (6-50) and 5- aminomethylbenzothiopyranoindazoles (51-61), are described and compared. Nearly all members of both series display excellent in vivo activity versus murine pancreatic adenocarcinoma 03 (Panc03) although there is little to distinguish the two series from each other. In both series there is no discernible relationship between structure and in vivo ...