Synthesis, antimicrobial activities and cytogenetic studies of newer diazepino quinoline derivatives via Vilsmeier–Haack reaction

R Nandhakumar, T Suresh, ALC Jude…

文献索引：Nandhakumar; Suresh; Jude, A.L. Calistus; Rajesh kannan; Mohan European Journal of Medicinal Chemistry, 2007 , vol. 42, # 8 p. 1128 - 1136

全文：HTML全文

被引用次数: 33

摘要

The study of the Vilsmeier–Haack reagent on 4-hydroxyquinaldines resulted in a new versatile intermediate 4-chloro-3-formyl-2-(2-hydroxy-ethene-1-yl) quinolines, which on further treatment with hydrazine hydrate yielded the desired diazepino quinoline derivatives. All the synthesized diazepino quinoline derivatives are screened for their antibacterial and antifungal activities. Cytogenetic analysis of the samples is also reported.