Bioorganic & medicinal chemistry

Recognition of RNA by triplex formation: divergent effects of pyrimidine C-5 methylation

S Wang, Y Xu, ET Kool

文献索引：Wang, Shaohui; Xu, Yanzheng; Kool, Eric T. Bioorganic and Medicinal Chemistry, 1997 , vol. 5, # 6 p. 1043 - 1050

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被引用次数: 6

摘要

In DNA triple helices, methylation at C-5 of thymine or cytosine is reported to have similar stabilizing effects for both bases. Here we show, however, that methylation of the same positions in RNA triplexes has distinctly different effects than in DNA. We have previously described the use of circular triplex-forming RNA oligonucleotides to recognize RNA sequences. Here it is shown that addition of C-5 methyl groups to uracils in these ...