Some hydroxylated derivatives of chlorpromazine

HM Grotta, TF Page, CJ Riggle…

文献索引：Grotta,H.M. et al. Journal of Heterocyclic Chemistry, 1967 , vol. 4, p. 611 - 618

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被引用次数: 9

摘要

Abstract As part of a program to determine the metabolic fate of chlorpromazine [2-chloro-10- (3-dimethylaminopropyl) phenothiazine](I), the synthesis of several hydroxylated derivatives of I was undertaken. This paper reports the preparation and structural verification of the 1- and 6-hydroxy and the desdimethyl 3-hydroxy derivative, and summarizes unsuccessful attempts to prepare the 4-hydroxy derivative of I.