Tetrahedron: Asymmetry

An enzyme-based synthesis of (S)-(−)-3-methyl-2-[(phenylsiilfonyl)-methyl] butyl phenyl sulfide and the stereochemical course of its alkylation

R Guevel, LA Paquette

文献索引：Guevel, Ronan; Paquette, Leo A. Tetrahedron: Asymmetry, 1993 , vol. 4, # 5 p. 947 - 956

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被引用次数: 7

摘要

Abstract The two title reactions have been explored. In the first instance, best results were achieved if the chloroacetate ester of 3-methyl-2 [(phenylsulfonyl) methyl]-1-butanol was subjected to enzymatic hydrolysis with lipase P30 (Amano). Subsequent conversion to the