A series of disubstituted cyclopentanones have been synthesized by the intramolecular Stetter reaction. Racemic substrates containing one chiral center were used, allowing us the opportunity to observe a parallel kinetic resolution in the synthesis of 2, 3-and 2, 4- disubstituted cyclopentanones. The Stetter reaction of 2, 5-disubstituted cyclopentanones proved to be substrate controlled, resulting in the selective formation of the cis- ...
