A series of aliphatic propargylamine derivatives has been synthesized. Some of them possess highly potent, irreversible, selective, inhibitory activity toward monoamine oxidase B (MAO-B). The potency of the inhibitors is related to chain length and substitution of a hydrogen on the terminal carbon of the aliphatic chain. MA0 inhibitory activity as assessed in vitro increased as the aliphatic carbon chain length increased. Substitution of a hydrogen ...
