Synthesis, antiviral activity, and mode of action of some 3-substituted 2, 5, 6-trichloroindole 2'-and 5'-deoxyribonucleosides

…, RG Ptak, JC Drach, LB Townsend

文献索引：Williams, John D.; Ptak, Roger G.; Drach, John C.; Townsend, Leroy B. Journal of Medicinal Chemistry, 2004 , vol. 47, # 23 p. 5773 - 5782

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被引用次数: 18

摘要

A series of chlorinated indole nucleosides has been synthesized and tested for activity against human cytomegalovirus (HCMV) and herpes simplex virus type-1 (HSV-1) and for cytotoxicity. The 2'-and 5'-deoxy derivatives of the reported 3-formyl-2, 5, 6-trichloro-1-(β-d- ribofuranosyl) indole (FTCRI) and 3-cyano-2, 5, 6-trichloro-1-(β-d-ribofuranosyl) indole (CTCRI) were synthesized by either a modification of the appropriate 3-unsubstituted ...