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The Journal of Organic Chemistry

N-Substituted 2, 2, 2-trifluoroethanimidic acid 1-methylethylidene hydrazides as synthetic blocks for trifluoromethylated nitrogen heterocycles: syntheses and oxidative …

K Uneyama, K Sugimoto

文献索引:Uneyama, Kenji; Sugimoto, Kouji Journal of Organic Chemistry, 1992 , vol. 57, # 22 p. 6014 - 6019

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被引用次数: 33

摘要

N-Substituted 2, 2, 2-trifluoroethanimidic acid l-methylethylidene hydrazides have been prepared and allowed to react wtih tert-butyl hypochlorite in CH2C1p N-Aryl-, N-alkyl-, and N- (methoxycarbony1) amidrazones 2-4 undergo three types of cyclizations via the initially formed N-chloro intermediates leading to 3-(trifluoro-methyl)-l, 2, 4-benzotriazines 6, 3- (trifluoromethyl)-5-alkyltriazoles 8 and 9, and 3-chloro-3-(trifluoromethyl)-4-