Tetrahedron Letters

InX 3-catalyzed haloamidation of vinyl arenes: a facile synthesis of α-bromo-and α-fluoroamides

JS Yadav, BVS Reddy, DN Chary, D Chandrakanth

文献索引：Yadav; Subba Reddy; Narasimha Chary; Chandrakanth Tetrahedron Letters, 2009 , vol. 50, # 10 p. 1136 - 1138

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被引用次数: 21

摘要

A variety of alkenes are converted into the corresponding α-fluoroamides in high yields by selectfluorTM in the presence of 10mol% of InF3 in nitrile solution. α-Bromoamides are obtained with NBS in the presence of 10mol% InBr3 under similar conditions. The use of Lewis acid in haloamidation significantly improved the yields and reaction rates.