Tetrahedron letters

Asymmetric dihydroxylation of disubstituted allenes

SA Fleming, R Liu, JT Redd

文献索引：Fleming, Steven A.; Liu, Renmao; Redd, J. Ty Tetrahedron Letters, 2005 , vol. 46, # 47 p. 8095 - 8098

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被引用次数: 16

摘要

Asymmetric dihydroxylation of 1, 1-disubstituted and 1, 3-disubstituted allenes can be used to synthesize chiral α-hydroxy ketones. We have also obtained α, α′-dihydroxy ketones with high enantioselectivity from 1, 3-disubstituted allenes. Low conversion of the dihydroxylation of chiral allenes can be used as a kinetic resolution of sterically hindered allenes.